Nanotopography draped microneedles infuse drug within the epidermis to access both the systemic and lymphatic capillaries. This creates an efficient mass transfer system and helps to avoid the inherent inefficiencies of subcutaneous drug delivery.
The Sofusa™ platform can be tuned to deliver controllable, consistent drug flow with potential to enable superior efficacy and fewer adverse events.
Kam, K.R., Walsh, L. A., Bock, S., Ollerenshaw, J., Ross, R.F., Desai, T.A.; “The Effect of Nanotopography on Modulating Protein Adsorption and the Fibrotic Response,” Tissue Engineering, Vol. 00/Num. 00; 2013.Learn More
Walsh, L., Ryu, J., Bock, S., Koval, M., Mauro, T., Ross, R., Desai, T. “Nanotopography Facilitates in Vivo Transdermal Delivery of High Molecular Weight Therapeutics through an Integrin-Dependent Mechanism,” Nano Letters, 2434-2441, 2015.Learn More
Kam, K.R., Walsh, L. A., Bock, S., Koval, M., Fischer, K.E., Ross, R.F., Desai, T.A.; “Nanostructure-Mediated Transport of Biologics across Epithelial Tissue: Enhancing Permeability via Nanotopography,” Nano Letters, Vol. 13, 164-171, 2013.Learn More
Melissa B. Aldrich, Fred C. Velasquez, Sunkuk Kwon, Ali Azhdarinia, Kenneth Pinkston, Barrett R. Harvey, Wenyaw Chan, John C. Rasmussen, Russell F. Ross, Caroline E. Fife and E. M. Sevick-Muraca; "Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis," Arthritis Research & Therapy, 19:116, 2017Learn More